Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis. | Available online http content 8 5 R138 Research article Failure of catecholamines to shift T-cell cytokine responses toward a Th2 profile in patients with rheumatoid arthritis Matthias Wahle1 Gesine Hanefeld1 Stephan Brunn1 Rainer H Straub2 Ulf Wagner1 Andreas Krause3 Holm Hantzschel1 and Christoph GO Baerwald1 Open Access Department of Internal Medicine IV University Hospital Leipzig Liebigstrasse 22 04103 Leipzig Germany Laboratory of Experimental Rheumatology and Neuroendocrino-Immunology Department of Internal Medicine I University Hospital Regensburg Franz-Josef-Strauss-Allee 11 93042 Regensburg Germany 3Immanuel Hospital Rheumatology Clinic Konigstrasse 63 14109 Berlin Germany Corresponding author Matthias Wahle Received 1 7 May 2006 Revisions requested 20 Jun 2006 Revisions received 11 Jul 2006 Accepted 6 Aug 2006 Published 6 Aug 2006 Arthritis Research Therapy 2006 8 R138 doi ar2028 This article is online at http content 8 5 R138 2006 Wahle et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract To further understand the role of neuro-immunological interactions in the pathogenesis of rheumatoid arthritis RA we studied the influence of sympathetic neurotransmitters on cytokine production of T cells in patients with RA. T cells were isolated from peripheral blood of RA patients or healthy donors HDs and stimulated via CD3 and CD28. Co-incubation was carried out with epinephrine or norepinephrine in concentrations ranging from 10 5 M to 10 11 M. Interferon IFN -y tumour necrosis factor TNF -a interleukin IL -4 and IL-10 were determined in the culture supernatant with enzyme-linked immunosorbent assay. In addition IFN-Y and IL-10 were .
