Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Novel IL10 gene family associations with systemic juvenile idiopathic arthritis. | Available online http content 8 5 R148 Research article Novel IL10 gene family associations with systemic juvenile idiopathic arthritis Marks Fife1 Ana Gutierrez1 Emma M Ogilvie1 Carmel JW Stock1 Jane M Samuel1 Wendy Thomson2 Lisa F Mack2 Cathryn M Lewis3 and Patricia Woo1 Centre of Pediatric and Adolescent Rheumatology Windeyer Institute for Medical Sciences University College London Cleveland Street London W1T 4JF UK 2ARC Epidemiology Unit University of Manchester Manchester UK 3Guy s Kings and St Thomas School of Medicine London UK Corresponding author MarkS Fife Received 1 0 May 2006 Revisions requested 21 Jun 2006 Revisions received 19 Jul 2006 Accepted 7 Sep 2006 Published 7 Sep 2006 Arthritis Research Therapy 2006 8 R148 doi ar2041 This article is online at http content 8 5 R148 2006 Fife et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Juvenile idiopathic arthritis JIA is the most common cause of chronic childhood disability and encompasses a number of disease subgroups. In this study we have focused on systemic JIA sJIA which accounts for approximately 11 of UK JIA cases. This study reports the investigation of three members of the IL10 gene family as candidate susceptibility loci in children with sJIA. DNA from 473 unaffected controls and 172 patients with sJIA was genotyped for a single nucleotide polymorphism SNP in IL19 and IL20 and two SNPs in IL10. We examined evidence for association of the four SNPs by single marker and haplotype analysis. Significant differences in allele frequency were observed between cases and controls for both IL10-1082 p and IL20-468 p . Furthermore examination of the .
