Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control study. | Available online http content 8 5 R151 Open Access Research article Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis a case control study Vokko P van Halm1 Michael T Nurmohamed2 Jos WR Twisk3 Ben AC Dijkmans1 and Alexandre E Voskuyl1 Department of Rheumatology VU University Medical Center Boelelaan 1117 Amsterdam 1085 HV The Netherlands department of Rheumatology Jan van Breemen Institute Jan van Breemen straat 2 Amsterdam 1 056 AB The Netherlands department of Clinical Epidemiology and Biostatistics VU University Medical Center Boelelaan 1117 Amsterdam 1085 HV The Netherlands Corresponding author Alexandre E Voskuyl Received 10 May 2006 Revisions requested 15 Jun 2006 Revisions received 21 Aug 2006 Accepted 20 Sep 2006 Published 20 Sep 2006 Arthritis Research Therapy 2006 8 R151 doi ar2045 This article is online at http content 8 5 R151 2006 van Halm et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Rheumatoid arthritis RA is characterized by inflammation and an increased risk for cardiovascular disease CVD . This study investigates possible associations between CVD and the use of conventional disease-modifying antirheumatic drugs DMARDs in RA. Using a case control design 613 RA patients 5 649 patient-years were studied 72 with CVD and 541 without CVD. Data on RA CVD and drug treatment were evaluated from time of RA diagnosis up to the first cardiovascular event or the end of the follow-up period. The dataset was categorized according to DMARD use sulfasalazine SSZ hydroxychloroquine HCQ or methotrexate MTX . Odds ratios ORs for CVD corrected for age
