Báo cáo khoa học: "SemiWhole brain radiotherapy with a conformational external beam radiation boost for lung cancer patients with 1-3 brain metastasis: a multi institutional study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiWhole brain radiotherapy with a conformational external beam radiation boost for lung cancer patients with 1-3 brain metastasis: a multi institutional study. | Casanova et al. Radiation Oncology 2010 5 13 http content 5 1 13 RADIATION ONCOLOGY RESEARCH Open Access Whole brain radiotherapy with a conformational external beam radiation boost for lung cancer patients with 1-3 brain metastasis a multi institutional study l l dthd I id d Cd d 1 7 h rd K ld-zcti mi2 .ihidd Ricuri3 chrietddhd nmhocci ire 4 Aloccid Pic-d2 ri irriioc lA ohor1 5 Nathalie Casanova Zoina Mazouni Sabine Bieri Christophe Coillbescure Alessia Pica Damien C Weber Abstract Background Tu determine the outcome uf patients with brain metastasis BM from lung cancer treated with an external beam radiotherapy boost RTB after whole brain radiotherapy WBRT . Methods A total of 53 BM patients with lung cancer were treated sequentially with WBRT and RTB between 1996 and 2008 according to our institutional protocol. Mean age was years. The median KPS was 90. Median recursive partitioning analysis RPA and graded prognostic assessment GPA grouping were 2 and respectively. Surgery was performed on 38 71 patients. The median number of BM was 1 range 1-3 . Median WBRT and RTB combined dose was 39 Gy range - 54 . Median follow-up was months. Results During the period of follow-up 37 70 patients died. The median overall survival OS was months. Only 13 patients failed in the brain. The majority of patients n 29 failed distantly. The 1-year OS -local control extracranial failure rates were and respectively. On univariate analysis improved OS was found to be significantly associated with total dose 39 Gy vs. 39 Gy p age 65 p absence of extracranial metastasis p GPA p KPS 90 p and RPA 2 p . On multivariate analysis total dose p and the absence of extracranial metastasis p retained statistical significance. Conclusions The majority of lung cancer patients treated with WBRT and RTB progressed extracranially. There might be a subgroup of younger patients with good performance .

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