Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: SemiNeo-adjuvant chemo-radiation of rectal cancer with Volumetric Modulated Arc Therapy: summary of technical and dosimetric features and early clinical experience. | Richetti et al. Radiation Oncology 2010 5 14 http content 5 1 14 RADIATION ONCOLOGY RESEARCH Open Access Neo-adjuvant chemo-radiation of rectal cancer with Volumetric Modulated Arc Therapy summary of technical and dosimetric features and early clinical experience 1 2 2 2 11 Antonella Richetti Antonella Fogliata Alessandro Clivio Giorgia Nicolini Gianfranco Pesce Emanuela Salati Eugenio Vanetti 2 Luca Cozzi2 Abstract Background To report about initial technical and clinical experience in preoperative radiation treatment of rectal cancer with volumetric modulated arcs with the RapidArc RA technology. Methods Twenty-five consecutive patients pts were treated with RA. All showed locally advanced rectal adenocarcinoma with stage T2-T4 N0-1. Dose prescription was 44 Gy in 22 fractions or 45 Gy in 25 fractions . Delivery was performed with single arc with a 6 MV photon beam. Twenty patients were treated preoperatively five did not receive surgery. Twenty-three patients received concomitant chemotherapy with oral capecitabine. A comparison with a cohort of twenty patients with similar characteristics treated with conformal therapy 3DC is presented as well. Results From a dosimetric point of view RA improved conformality of doses CI95 vs. for RA and 3DC presented similar target coverage with lower maximum doses significant sparing of femurs and significant reduction of integral and mean dose to healthy tissue. From the clinical point of view surgical reports resulted in a down-staging in 41 of cases. Acute toxicity was limited to Grade 1-2 diarrhoea in 40 and Grade 3 in 8 of RA pts 45 and 5 of 3DC pts compatible with known effects of concomitant chemotherapy. RA treatments were performed with an average of vs. min of 3DC. Conclusion RA proved to be a safe qualitatively advantageous treatment modality for rectal cancer showing some improved results in dosimetric aspects. Background Pre-operative chemo-radiotherapy of rectal cancer in .
