Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. | Available online http content 8 6 R1 72 Open Access Research article The proinflammatory cytokines IL-1 p and TNF-a induce the expression of Synoviolin an E3 ubiquitin ligase in mouse synovial fibroblasts via the Erk1 2-ETS1 pathway Beixue Gao1 Karen Calhoun1 and Deyu Fang1 2 Department of Otolaryngology-Head and Neck Surgery University of Missouri School of Medicine One Hospital Drive Columbia MO 65212 USA department of Molecular Microbiology and Immunology University of Missouri School of Medicine One Hospital Drive Columbia MO 65212 USA Corresponding author Deyu Fang FangD@ Received 13 Jun 2006 Revisions requested 13 Jul 2006 Revisions received 10 Oct 2006 Accepted 14 Nov 2006 Published 14 Nov 2006 Arthritis Research Therapy 2006 8 R172 doi ar2081 This article is online at http content 8 6 R1 72 2006 Gao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The overgrowth of synovial tissues is critical in the pathogenesis of rheumatoid arthritis RA . The expression of Synoviolin SYN an E3 ubiquitin ligase is upregulated in arthritic synovial fibroblasts and is involved in the overgrowth of synovial cells during RA. However the molecular mechanisms involved in the elevated SYN expression are not known. Here we found that SYN expression is elevated in the synovial fibroblasts from mice with collagen-induced arthritis CIA . The proinflammatory cytokines interleukin IL -1P and tumor necrosis factor-a TNF-a induce SYN expression in mouse synovial fibroblasts. Cultivation of mouse synovial fibroblasts with IL-1P activates mitogen-activated protein kinases including extra-cellular signal-regulated kinase Erk JNK c-Jun N-terminal kinase and p38 while .
