Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach. | Available online http content 8 6 R1 75 Research article Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach Kosuke Matsuo1 2 Yang Xiang1 Hiroshi Nakamura1 Kayo Masuko1 Kazuo Yudoh1 Koji Noyori2 Kusuki Nishioka3 Tomoyuki Saito2 and Tomohiro Kato1 Open Access 1 Department of Bioregulation Proteomics Institute of Medical Science St. Marianna University School of Medicine Sugao 2-16-1 Miyamae Kawasaki Kanagawa 216-8512 Japan 2Musculoskeletal Science Yokohama City University Graduate School of Medicine Fukuura3-9 Kanazawa Yokohama Kanagawa 236-0004 Japan 3Department of Frontier Medicine Institute of Medical Science St. Marianna University School of Medicine Sugao 2-16-1 Miyamae Kawasaki Kanagawa 216-851 2 Japan Corresponding author Tomohiro Kato t3kato@ Received 13 Jul 2006 Revisions requested 3 Aug 2006 Revisions received 2 Nov 2006 Accepted 27 Nov 2006 Published 27 Nov 2006 Arthritis Research Therapy 2006 8 R175 doi ar2085 This article is online at http content 8 6 R175 2006 Matsuo et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Recently autoantibodies to some citrullinated autoantigens have been reported to be specific for rheumatoid arthritis RA . However an entire profile of and autoimmunity of the citrullinated proteins have been poorly understood. To understand the profile we examined citrullinated autoantigens by a proteomic approach and further investigated the significance of citrullination in antigenicity of one of the autoantigens. Specifically we detected citrullinated autoantigens in synovial tissue of a patient with RA by twodimensional electrophoresis and Western .
