Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein. | Available online http content 8 6 R181 Research article The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein Kelitha Maxis Aline Delalandre Johanne Martel-Pelletier Jean-Pierre Pelletier Nicolas Duval and Daniel Lajeunesse Unite de recherche en Arthrose Centre de recherche du Centre Hospitalier de l Universite de Montreal Hôpital Notre-Dame 1560 rue Sherbrooke Est Montreal Quebec Canada H2L 4M1 Corresponding author Daniel Lajeunesse Received 5 May 2006 Revisions requested 1 Jun 2006 Revisions received 24 Nov 2006 Accepted 8 Dec 2006 Published 8 Dec 2006 Arthritis Research Therapy 2006 8 R181 doi ar2092 This article is online at http content 8 6 R181 2006 Maxis et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Osteoarthritis OA is characterized by articular cartilage degradation and hypertrophic bone changes with osteophyte formation and abnormal bone remodeling. Two groups of OA patients were identified via the production of variable and opposite levels of prostaglandin E2 PGE2 or leukotriene B4 LTB4 by subchondral osteoblasts PGE2 levels discriminating between low and high subgroups. We studied whether the expression of 5-lipoxygenase 5-LO or 5-LO-activating protein FLAP is responsible for the shunt from prostaglandins to leukotrienes. FLAP mRNA levels varied in low and high OA groups compared with normal whereas mRNA levels of 5-LO were similar in all osteoblasts. Selective inhibition of cyclooxygenase-2 COX-2 with NS-398-stimulated FLAP expression in the high OA osteoblasts subgroup
