Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Adjuvant chemo-radiation for gastric adenocarcinoma: an institutional experience. | Aftimos et al. Radiation Oncology 2010 5 50 http content 5 1 50 RADIATION ONCOLOGY RESEARCH Open Access Adjuvant chemo-radiation for gastric adenocarcinoma an institutional experience Philippe G Aftimos 1 Elie A Nasr2 Dolly I Nasr2 Roger J Noun3 Fady L Nasr1 Marwan G Ghosn1 Joelle A El Helou2 and Georges Y Chahine1 Abstract Background Studies have shown that surgery alone is less than satisfactory in the management of early gastric cancer with cure rates approaching 40 . The role of adjuvant therapy was indefinite until three large randomized controlled trials showed the survival benefit of adjuvant therapy over surgery alone. Chemoradiation therapy has been criticized for its high toxicity. Methods 24 patients diagnosed between September 2001 and July 2007 were treated with adjuvant chemoradiation. 18 patients had the classical MacDonald regimen of 4500 cGy of XRT and chemotherapy with 5-fluorouracil 5FU and leucovorin while chemotherapy consisted of 5FU Cisplatin for 6 patients. Results This series consisted of non-metastatic patients 17 females and 7 males with a median age of years. 23 patients 96 had a performance status of 0 or 1. The full course of radiation therapy 4500 cGy was completed by 22 patients . Only 7 patients completed the total planned courses of chemotherapy. 2 local relapses 10 2 regional relapses 10 and 2 distant relapses 10 were recorded. Time to progression has not been reached. 9 patients died during follow-up with a median overall survival of 75 months. Patients lost a mean of 4 Kgs during radiation therapy. We recorded 6 episodes of febrile neutropenia and the most frequent toxicity was gastro-intestinal in 17 patients with 9 36 patients suffering grade 3 or 4 toxicity and 5 patients 20 suffering from grade 3 or 4 neutropenia. 4 17 patients required total parenteral nutrition for a mean duration of 20 days. 4 patients suffered septic shock 17 and 1 patient developed a deep venous thrombosis and
