Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Intensity-Modulated Radiotherapy in Patients with Cervical Cancer. An intra-individual Comparison of Prone and Supine Positioning. | Stromberger et al. Radiation Oncology 2010 5 63 http content 5 1 63 RADIATION ONCOLOGY RESEARCH Open Access Intensity-Modulated Radiotherapy in Patients with Cervical Cancer. An intra-individual Comparison of Prone and Supine Positioning Carmen Stromberger 1 Yves Kom1 Michael Kawgan-Kagan1 Tristan Mensing1 Ulrich Jahn1 Achim Schneider2 Volker Budach1 Christhardt Kohler2 and Simone Marnitz 1 Abstract Background Chemoradiation for cervical cancer patients is associated with considerable gastrointestinal toxicity. Intensity-modulated radiotherapy IMRT has demonstrated superiority in terms of target coverage and normal tissue sparing in comparison to conventional 3D planning in gynaecological malignancies. Whether IMRT in prone PP or supine position SP might be beneficial for cervical cancer patients remains partially unanswered. Methods 10 patients on FIGO stage IB-III cervical cancer 6 patients for definitive and 4 patients for adjuvant external beam pelvic RT were planned in PP and SP using a 7-field IMRT technique. IMRT plans for PP and SP mean dose Dmean Gy were optimized in terms of PTV coverage 1st priority and small bowel sparing 2nd priority . A comparison of DVH parameters for PTV small bowel bladder and rectum was performed. Results The comparison showed a similar PTV coverage of 95 of the prescribed dose and for target conformity in IMRT plans PR SP . PTV rectum and bladder volumes were comparable for PP and SP Significantly larger volumes of small bowel were found in PP 436 cc 35 p . PP decreased the volume of small bowel at Gy p and increased the rectum volumes covered by doses from 10-40 Gy p the was 5 in both treatment positions. Bladder sparing was significant better at Gy p for PP Conclusion In this dosimetric study we demonstrated that pelvic IMRT in prone position for patients with cervical cancer seems to be beneficial in reducing small bowel volume at doses 20 Gy while providing .
