Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial cancer. | Dickler et al. Radiation Oncology 2010 5 67 http content 5 1 67 RADIATION ONCOLOGY RESEARCH Open Access Prospective multi-center trial utilizing electronic brachytherapy for the treatment of endometrial cancer Adam Dickler 1 Mohamed Y Puthawala2 John P Thropay3 Ajay Bhatnagar4 and Gary Schreiber5 Abstract Background A modified form of high dose rate HDR brachytherapy has been developed called Axxent Electronic Brachytherapy EBT . EBT uses a kilovolt X-ray source and does not require treatment in a shielded vault or a HDR afterloader unit. A multi-center clinical study was carried out to evaluate the success of treatment delivery safety and toxicity of EBT in patients with endometrial cancer. Methods A total of 15 patients with stage I or II endometrial cancer were enrolled at 5 sites. Patients were treated with vaginal EBT alone or in combination with external beam radiation. Results The prescribed doses of EBT were successfully delivered in all 15 patients. From the first fraction through 3 months follow-up there were 4 CTC Grade 1 adverse events and 2 CTC Grade II adverse events reported that were EBT related. The mild events reported were dysuria vaginal dryness mucosal atrophy and rectal bleeding. The moderate treatment related adverse events included dysuria and vaginal pain. No Grade III or IV adverse events were reported. The EBT system performed well and was associated with limited acute toxicities. Conclusions EBT shows acute results similar to HDR brachytherapy. Additional research is needed to further assess the clinical efficacy and safety of EBT in the treatment of endometrial cancer. Introduction Endometrial cancer is the most common gynecologic cancer and an estimated 42 160 new cases of endometrial cancer were diagnosed in 2009 1 . The standard management for endometrial cancer is a total abdominal hysterectomy and bilateral salpingo-oophorectomy TAH-BSO with or without lymph node sampling. The vagina is the most common site of .
