Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers. | Jiang et al. Radiation Oncology 2010 5 68 http content 5 1 68 RADIATION ONCOLOGY RESEARCH Open Access CT-guided iodine-125 seed permanent implantation for recurrent head and neck cancers 11 1 t 1 2t 2 A -S 1 1 Yu L Jiang Na Meng Jun J Wang Ping Jiang Hui SH Yuan Chen Liu Ang Qu Rui J Yang Abstract Background To investigate the feasibility and safety of 125I seed permanent implantation for recurrent head and neck carcinoma under CT-guidance. Results A retrospective study on 14 patients with recurrent head and neck cancers undergone 125I seed implantation with different seed activities. The post-plan showed that the actuarial D90 of 125I seeds ranged from 90 to 218 Gy median Gy . The follow-up was 3 to 60 months median 13 months . The median local control was 18 months 95 CI months and the 1- 2- 3- and 5- year local controls were 52 39 39 and 39 respectively. The 1- 2- 3- and 5- survival rates were 65 39 39 and 39 respectively with a median survival time of 20 months 95 CI months . Of all patients 4 14 died of local recurrence 1 14 died of metastases one patient died of hepatocirrhosis and 8 patients are still alive to the date of data analysis. Conclusion CT-guided 125I seed implantation is feasible and safe as a salvage or palliative treatment for patients with recurrent head and neck cancers. Background Most patients who have ever undergone surgery for head and neck cancer or those local advanced or regional recurrence cancer patients received surgery combined with adjuvant external-beam radiotherapy EBRT 1 2 . Management of patients with recurrent head and neck cancers after surgery EBRT and adjuvant chemotherapy is a challenge for clinical oncologists. Salvage surgery is often technically feasible after the patients treated with full doses of EBRT but the curative potential of surgery alone is low further the morbidity is high 3 . Redelivery of effective doses of EBRT is difficult because of the limited .
