Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters. | Kao et al. Radiation Oncology 2010 5 76 http content 5 1 76 RADIATION ONCOLOGY RESEARCH Open Access 18F-FDG PET CT-based gross tumor volume definition for radiotherapy in head and neck Cancer a correlation study between suitable uptake value threshold and tumor parameters 13 15 2 5 15 2 5 2 Chia-Hung Kao 1 Te-Chun Hsieh 1 Chun-Yen Yu Kuo-Yang Yen 1 Shih-Neng Yang Yao-Ching Wang Ji-An Liang2 3 Chun-Ru Chien2 3 Shang-Wen Chen2 3 4 Abstract Background To define a suitable threshold setting for gross tumor volume GTV when using 18Fluoro-deoxyglucose positron emission tomography and computed tomogram PET CT for radiotherapy planning in head and neck cancer HNC . Methods Fifteen HNC patients prospectively received PET CT simulation for their radiation treatment planning. Biological target volume BTV was derived from PET CT-based GTV of the primary tumor. The BTVs were defined as the isodensity volumes when adjusting different percentage of the maximal standardized uptake value SUVmax excluding any artifact from surrounding normal tissues. CT-based primary GTV C-pGTV that had been previously defined by radiation oncologists was compared with the BTV. Suitable threshold level sTL could be determined when BTV value and its morphology using a certain threshold level was observed to be the best fitness of the C-pGTV. Suitable standardized uptake value sSUV was calculated as the sTL multiplied by the SUVmax. Results Our result demonstrated no single sTL or sSUV method could achieve an optimized volumetric match with the C-pGTV. The sTL was 13 to 27 mean 19 whereas the sSUV was to mean . The sTL was inversely correlated with the SUVmax sTL Ln SUVmax R2 . The sSUV showed a linear correlation with the SUVmax sSUV SUVmax R2 . The sTL was not associated with the value of C-pGTVs. Conclusion In PET CT-based BTV for HNC a suitable threshold or SUV level can be established by correlating with SUVmax rather than .
