Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinoma. | Bachireddy et al. Radiation Oncology 2010 5 105 http content 5 1 105 RADIATION ONCOLOGY RESEARCH Open Access Orthovoltage intraoperative radiation therapy for pancreatic adenocarcinoma 1 t P s T- 1 t 1 1 1 1 Pavan Bachireddy t Diane Tseng Melissa Horoschak Daniel T Chang Albert C Koong Daniel S Kapp Phuoc T Tran 2 Abstract Purpose To analyze the outcomes of patients from a single institution treated with surgery and orthovoltage intraoperative radiotherapy IORT for pancreatic adenocarcinoma. Methods We retrospectively reviewed 23 consecutive patients from 1990-2001 treated with IORT to 23 discrete sites with median and mean follow up of and 21 months respectively. Most tumors were located in the head of the pancreas 83 and sites irradiated included tumor bed 57 vessels 26 both the tumor bed vessels 13 and other 4 . The majority of patients 83 had IORT at the time of their definitive surgery. Three patients had preoperative chemoradiation 13 . Orthovoltage X-rays 200-250 kVp were employed via individually sized and beveled cone applicators. Additional mean clinical characteristics include age 64 range 41-81 tumor size 4 cm range and IORT dose 1106 cGy range 600-1500 . Post-operative external beam radiation EBRT or chemotherapy was given to 65 and 76 of the assessable patients respectively. Outcomes measured were infield control IFC loco-regional control LRC distant metastasis free survival DMFS overall survival OS and treatment-related complications. Results Kaplan-Meier KM 2-year IFC LRC DMFS and OS probabilities for the whole group were 83 61 26 and 27 respectively. Our cohort had three grade 3-5 complications associated with treatment surgery and IORT . Conclusions Orthovoltage IORT following tumor reductive surgery is reasonably well tolerated and seems to confer in-field control in carefully selected patients. However distant metastases remain the major problem for patients with pancreatic adenocarcinoma. Background Pancreatic .
