Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case. | Gousias et al. Radiation Oncology 2010 5 114 http content 5 1 114 RADIATION ONCOLOGY RESEARCH Open Access Factors of influence upon overall survival in the treatment of intracranial MPNSTs. Review of the literature and report of a case I I r I ri ir 1 t I p 21 A re I I -1 IZ r 3 Dizz M I zW1 If 4 I A Ỉ z5 D I 14 14 IZz I f C1 I onstantinos Gousias Jan Bostrom Anna Kovacs Pitt Niehusmann Ingo Wagner Rudolf ixiisiOT Abstract Background Intracranial malignant peripheral nerve sheath tumors are rare entities that carry a poor prognosis. To date there are no established therapeutic strategies for these tumors. Methods We review the present treatment modalities and present the current therapeutic dilemmas. We perform a statistical analysis to evaluate the prognostic factors for Overall Survival of these patients. Additionally we present our experience with a 64-year-old man with a MPNST of the left cerebellopontine angle. Results To our best knowledge forty three patients with intracranial MPNSTs including our case have been published in the international literature. Our analysis showed gross total resection radiotherapy and female gender to be beneficial prognostic factors of survival in the univariate analysis. Gross total resection was recognized as the only independent predictor of prolonged Overall Survival. In our case we performed a gross total resection followed for the first time by stereotactically guided radiotherapy. Conclusion Considering the results of the statistical analysis and the known advantages of the stereotaxy we suggest aggressive surgery followed by stereotactically guided radiotherapy as therapy of choice. Background Malignant Peripheral Nerve Sheath Tumors MPNST usually arise de novo or from a malignant transformation of a neurofibroma. Rarely MPNSTs may arise from schwannoma ganglioneuroma or phaeochromocytoma 1 2 . Incidence rates of MPNSTs are identified at less than 1 106 year with the majority of cases located in the .
