Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy: a retrospective case series. | See et al. Radiation Oncology 2011 6 25 http content 6 1 25 RESEARCH RADIATION ONCOLOGY Open Access Acute toxicity of second generation HIV protease-inhibitors in combination with radiotherapy a retrospective case series Alfred P SeeH Jing Zeng2t Phuoc T Tran2 3 Michael Lim1 3 Abstract Background There is little data on the safety of combining radiation therapy and human immunodeficiency virus HIV protease inhibitors to treat cancers in HIV-positive patients. We describe acute toxicities observed in a series of HIV-positive patients receiving modern radiation treatments and compare patients receiving HIV protease inhibitors PI with patients not receiving HIV PIs. Methods By reviewing the clinical records beginning January 1 2009 from the radiation oncology department we identified 29 HIV-positive patients who received radiation therapy to 34 body sites. Baseline information treatment regimen and toxicities were documented by review of medical records patient age histology and source of the primary tumor HIV medication regimen pre-radiation CD4 count systemic chemotherapy radiation therapy dose and fractionation irradiated body region toxicities and duration of follow-up. Patients were grouped according to whether they received concurrent HIV PIs and compared using Pearson s chi-square test. Results At baseline the patients in the two groups were similar with the exception of HIV medication regimens CD4 count and presence of AIDS-defining malignancy. Patients taking concurrent PIs were more likely to be taking other HIV medications p and have CD4 count 500 p . Patients taking PIs were borderline less likely to have an AIDS-defining malignancy p . After radiation treatment 100 acute toxicities were observed and were equally common in both groups 64 median 3 per patient IQR 1-7 with PIs 36 median 3 per patient IQR 2-3 without PIs . The observed toxicities were also equally severe in the two groups Grades I II III respectively 30 30
