Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas. | Minniti et al. Radiation Oncology 2011 6 36 http content 6 1 36 RADIATION ONCOLOGY RESEARCH Open Access Fractionated stereotactic conformal radiotherapy for large benign skull base meningiomas 13 1 2 1 3 I z- . 3 Giuseppe Minniti Enrico Clarke Luigi Cavallo Mattia Falchetto Osti Vincenzo Esposito Gianpaolo Cantore Paolo Cappabianca2 and Riccardo Maurizi Enrici1 Abstract Purpose to assess the safety and efficacy of fractionated stereotactic radiotherapy FSRT for large skull base meningiomas. Methods and Materials Fifty-two patients with large skull base meningiomas aged 34-74 years median age 56 years were treated with FSRT between June 2004 and August 2009. All patients received FSRT for residual or progressive meningiomas more than 4 centimeters in greatest dimension. The median GTV was cm3 range cm3 and the median PTV was cm3 range cm3 . Treatment volumes were achieved with 5-8 noncoplanar beams shaped using a micromultileaf collimator MLC . Treatment was delivered in 30 daily fractions over 6 weeks to a total dose of 50 Gy using 6 MV photons. Outcome was assessed prospectively. Results At a median follow-up of 42 months range 9-72 months the 3-year and 5-year progression-free survival PFS rates were 96 and 93 respectively and survival was 100 . Three patients required further debulking surgery for progressive disease. Hypopituitarism was the most commonly reported late complication with a new hormone pituitary deficit occurring in 10 19 of patients. Clinically significant late neurological toxicity was observed in 3 patients consisting of worsening of pre-existing cranial deficits. Conclusion FSRT as a high-precision technique of localized RT is suitable for the treatment of large skull base meningiomas. The local control is comparable to that reported following conventional external beam RT. Longer follow-up is required to assess long term efficacy and toxicity particularly in terms of potential reduction of
