Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Outcome of thyroid associated ophthalmopathy treated by radiation therapy. | Abboud et al. Radiation Oncology 2011 6 46 http content 6 1 46 RADIATION ONCOLOGY SHORT REPORT Open Access Outcome of thyroid associated ophthalmopathy treated by radiation therapy Mirna Abboud1 Asma Arabi2 Ibrahim Salti2 and Fady Geara1 Abstract Thyroid associated orbitopathy is a common manifestation of Graves disease. Many options can be considered for treatment. In this case series we reviewed the medical records of 17 patients who received radiation therapy RT for GO in a tertiary care center between 1997 and 2007. All patients received 20 Gy to both orbits and 12 of them 71 had already received one or more trials of steroid therapy prior to RT. After a median follow-up of 2 years a subjective improvement in exophthalmos and vision was reported by all patients at the end of RT but only 3 patients reported a decrease in their diplopia immediately after therapy. Symptoms continued to improve with time in many patients 22 had complete reversal of their symptoms and signs and the remaining 78 had partial improvement. Two patients developed recurrent signs and symptoms both of them were smokers who continued to smoke after treatment. About 60-65 of patients responded favorably to RT alone which increased to 87-97 when RT is combined with steroids. No patients developed late toxicity during the follow-up period. We conclude that RT is an effective treatment option in GO even in patients who failed previous treatment with steroids or surgical decompression. Based on our own clinical experiences and the literature data the combination of RT and intravenous corticosteroid administration may improve the response rate. Introduction Thyroid associated orbitopathy TAO is the most common extrathyroidal manifestation of Graves disease and continues to be a dilemma with regard to its pathogenesis and its therapy. Clinically evident ophthalmopathy occurs in 10 to 25 of patients with Graves thyrotoxicosis. This prevalence may increase up to 45 if eyelid .
