Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer. | Xia et al. Radiation Oncology 2011 6 50 http content 6 1 50 RADIATION ONCOLOGY RESEARCH Open Access The effect of bioequivalent radiation dose on survival of patients with limited-stage small-cell lung cancer Bing Xia Gui-Yuan Chen Xu-Wei Cai Jian-Dong Zhao Huan-Jun Yang Min Fan Kuai-Le Zhao and Xiao-Long Fu Abstract Background To investigate the biological radiation dose-response for patients of limited-stage small-cell lung cancer LS-SCLC treated with high radiation dose. Methods Two hundred and five patients of LS-SCLC treated with sequential chemotherapy and thoracic radiotherapy with involved-field between 1997 and 2006 were reviewed retrospectively. Biologically effective dose BED was calculated for dose homogenization and was corrected with the factor of overall radiation time. Patients were divided into low BED group n 70 and high BED group n 135 with a cut-off of BED 57 Gy equivalent to 60 Gy in 30 fractions over 40 days . Outcomes of the two groups were compared. Results Median follow-up was months for all analyzable patients and months for surviving patients. Considering all patients median survival was months 95 confidence interval months 2- and 5-year survival rates were and respectively. Patients in high BED group had a significantly better local control p progression-free survival p and overall survival p with a trend toward improved distant-metastasis free survival p . Multivariable Cox regression demonstrated that age p KPS p weight loss p and BED p were significant predictors of overall survival. Conclusions Our data showed that a high BED was significantly associated with favourable outcomes in the Chinese LS-SCLC population indicating that a positive BED-response relationship still existed even in a relatively high radiation dose range. Background Although concurrent thoracic radiotherapy TRT combined with chemotherapy represents the standard of
