Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Clostridium difficile-associated diarrhea in radiooncology: an underestimated problem for the feasibility of the radiooncological treatment? | Hautmann et al. Radiation Oncology 2011 6 89 http content 6 1 89 RADIATION ONCOLOGY RESEARCH Open Access Clostridium difficile-associated diarrhea in radiooncology an underestimated problem for the feasibility of the radiooncological treatment Matthias G Hautmann Matthias Hipp and Oliver Kolbl Background and Purpose Over the last years an increasing incidence of Clostridium difficile-associated diarrhea CDAD has been reported. Especially haematology-oncology patients are at risk of developing CDAD. The aim of this analysis is to determine the incidence of CDAD in radiooncological patients and to find out what relevance CDAD has for the feasibility of the radiooncological treatment as well as to detect and describe risk factors. Patients and Methods In a retrospective analysis from 2006 to 2010 34 hospitalized radiooncological patients could be identified having CDAD. The risk factors of these patients were registered the incidence was calculated and the influence on the feasibility of the radiooncological therapy was evaluated. Induced arrangements for prophylaxis of CDAD were identified and have been correlated with the incidence. Results The incidence of CDAD in our collective is 1 6 . Most of the patients suffering from a CDAD were treated for carcinoma in the head and neck area. Common risk factors were antibiotics proton pump inhibitors cytostatic agents and tube feeding. Beside a high rate of electrolyte imbalance and hypoproteinemia a decrease of general condition was frequent. 12 34 patients had a prolonged hospitalization in 14 34 patients radiotherapy had to be interrupted due to CDAD. In 21 of 34 patients a concomitant chemotherapy was planned. 4 21 patients could receive all of the planned cycles and only 2 21 patients could receive all of the planned cycles in time. 4 34 patients died due to CDAD. In 4 34 patients an initially curative treatment concept has to be changed to a palliative concept. With intensified arrangements for .
