Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Upfront systemic chemotherapy and preoperative short-course radiotherapy with delayed surgery for locally advanced rectal cancer with distant metastases. | Shin et al. Radiation Oncology 2011 6 99 http content 6 1 99 RADIATION ONCOLOGY SHORT REPORT Open Access Upfront systemic chemotherapy and preoperative short-course radiotherapy with delayed surgery for locally advanced rectal cancer with distant metastases 12 3 3 3 1 Sang Joon Shin Hong In Yoon Nam Kyu Kim Kang Young Lee Byung Soh Min Joong Bae Ahn Ki Chang Keum 2 and Woong Sub Koom2 Abstract Background Choosing the most effective approach for treating rectal cancer with mesorectal fascia MRF involvement or closeness and synchronous distant metastases is a current clinical challenge. The aim of this retrospective study was to determine if upfront systemic chemotherapy and short-course radiotherapy RT with delayed surgery enables R0 resection. Methods Between March 2009 and October 2009 six patients were selected for upfront chemotherapy and shortcourse RT 5 X 5 Gy with delayed surgery. The patients had locally advanced primary tumors with MRF involvement or closeness as well as synchronous and potentially resectable distant metastases. Chemotherapy was administered to five patients between the end of the RT and surgery. All patients underwent total mesorectal excision TME . Results The median patient age was 54 years range 39-63 . All primary and metastatic lesions were resected simultaneously. The median duration between short-course RT and surgery was 13 weeks range 7-18 . R0 resection of rectal lesions was achieved in 5 patients. One patient who had a very low-lying tumor had an R1 resection. The median follow-up duration for all patients was months range . One patient developed liver metastasis at months. There have been no local recurrences or deaths. Conclusions Upfront chemotherapy and short course RT with delayed surgery is a valuable alternative treatment approach for patients with MRF involvement or closeness of rectal cancer with distant metastases. Keywords short-course radiotherapy delayed surgery locally .
