Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Helical tomotherapy in the treatment of pediatric malignancies: a preliminary report of feasibility and acute toxicity. | Mesbah et al. Radiation Oncology 2011 6 102 http content 6 1 102 RADIATION ONCOLOGY RESEARCH Open Access Helical tomotherapy in the treatment of pediatric malignancies a preliminary report of feasibility and acute toxicity 11 1 1 1 1 Latifa Mesbah Raúl Matute Sergey Usychkin Immacolata Marrone Fernando Puebla Cristina Minguez Rafael García1 Graciela García1 César Beltrán1 and Hugo Marsiglia1 2 3 Abstract Background Radiation therapy plays a central role in the management of many childhood malignancies and Helical Tomotherapy HT provides potential to decrease toxicity by limiting the radiation dose to normal structures. The aim of this article was to report preliminary results of our clinical experience with HT in pediatric malignancies. Methods In this study 66 consecutive patients younger than 14 years old treated with HT at our center between January 2006 and April 2010 have been included. We performed statistical analyses to assess the relationship between acute toxicity graded according to the RTOG criteria and several clinical and treatment characteristics such as a dose and irradiation volume. Results The median age of patients was 5 years. The most common tumor sites were central nervous system 57 abdomen 17 and thorax 6 . The most prevalent histological types were medulloblastoma 16 patients neuroblastoma 9 patients and rhabdomyosarcoma 7 patients . A total of 52 patients were treated for primary disease and 14 patients were treated for recurrent tumors. The majority of the patients 72 were previously treated with chemotherapy. The median prescribed dose was 51 Gy range 10-70 Gy . In 81 of cases grade 1 or 2 acute toxicity was observed. There were 11 cases 16 6 of grade 3 hematological toxicity two cases of grade 3 skin toxicity and one case of grade 3 emesis. Nine patients 13 6 had grade 4 hematological toxicity. There were no cases of grade 4 non-hematological toxicities. On the univariate analysis total dose and craniospinal .
