Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: On the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatment. | Fogliata et al. Radiation Oncology 2011 6 103 http content 6 1 103 RADIATION ONCOLOGY RESEARCH Open Access On the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatment Antonella Fogliata Giorgia Nicolini Alessandro Clivio Eugenio Vanetti and Luca Cozzi Abstract Background A new algorithm for photon dose calculation Acuros XB has been recently introduced in the Eclipse Varian treatment planning system allowing similarly to the classic Monte Carlo methods for accurate modelling of dose deposition in media. Aim of the present study was the assessment of its behaviour in clinical cases. Methods Datasets from ten breast patients scanned under different breathing conditions free breathing and deep inspiration were used to calculate dose plans using the simple two tangential field setting with Acuros XB in its versions 10 and 11 and the Anisotropic Analytical Algorithm AAA for a 6MV beam. Acuros XB calculations were performed as dose-to-medium distributions. This feature was investigated to appraise the capability of the algorithm to distinguish between different elemental compositions in the human body lobular vs. adipose tissue in the breast lower deep inspiration condition vs. higher free breathing condition densities in the lung. Results The analysis of the two breast structures presenting densities compatible with muscle and with adipose tissue showed an average difference in dose calculation between Acuros XB and AAA of with AAA predicting higher dose than Acuros XB for the muscle tissue the lobular breast while the difference for adipose tissue was negligible. From histograms of the dose difference plans between AAA and Acuros XB version 10 the dose of the lung portion inside the tangential fields presented an average difference of in the free breathing conditions increasing to for the deep inspiration cases with AAA predicting higher doses than Acuros XB. In lung tissue significant differences
