Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Toxicity report of once weekly radiation therapy for low-risk prostate adenocarcinoma: preliminary results of a phase I/II trial. | Menkarios et al. Radiation Oncology 2011 6 112 http content 6 1 112 RADIATION ONCOLOGY RESEARCH Open Access Toxicity report of once weekly radiation therapy for low-risk prostate adenocarcinoma preliminary results of a phase I II trial tỉTHx K Aon Iz2 rirt tc1 Pri Virino i lit 2 Minnl c Rmchot 3 HrnwiH l-IA Mm laon-Doi li Rtỉ h n 4 KA rim Inlicnoi ir4 Cathy Menkdiios i ic viyiieduiL Nicolds Biociiet Ddvid HA Nguyen Jedn rdul Ddiidiy Mdijoiy Jolicoeui Marie-Claude Deduchemin4 Hugo Villeneuve4 Thu Vdn Nguyen4 Beindid Fortin1 did Cdiole Ldmbert4 Abstract Background Inciedsing clinicdl ddid supports d low a p ratio foi piostdte ddenocdicinomd potentidlly lowei Lhdn thdt of suiiounding noimdl tissues. A hypofidcliondled weekly iddidlion Lheidpy RT schedule should result in improved lumoui control ieduced dcule toxicity dnd simildi oi deciedsed ldle effects. We report the toxicity profile of such tiedtment. Materials and Methods We conducted d multi-institution phdse I II tiidl of thiee-dimensiondl confoimdl iddidtion theidpy 3D-CRT foi fdvouidble-iisk piostdte cdncei T1d-T2d Gledson 6 dnd PSA 10 ng ml . RT consisted of 45 Gy in nine 5 Gy fractions once weekly. Piimdiy end-points weie fedsibility dnd ldte gdstiointestindl GI toxicity RTOG scdle while seconddiy end-points included dcute GI toxicity dcute dnd ldte genitouiindiy GU toxicity biochemicdl control dnd suivivdl. Results Between 2006 dnd 2008 80 pdtients weie tiedted. No tiedtment inteiiuptions occuiied. The medidn follow-up is 33 months idnge 20-51 . Mdximdl gidde 1 2 dnd 3 dcute 3 months GU toxicity wds 29 31 dnd 5 respectively no gidde 4 . Acute GI gidde 1 toxicity wds reported in 30 while gidde 2 occuiied in 14 no gidde 3 oi 4 . Ciude ldte gidde 3 toxicity idtes dt 31 months weie 2 foi both GU dnd GI toxicity. Cumuldtive ldte gidde 3 GI toxicity dt 3 yedis wds 11 . Two pdtients hdd PSA fdiluie dccoiding to the Phoenix definition. The thiee-yedi dctudiidl biochemicdl control idte is 97 . .
