Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM). | Adeberg et al. Radiation Oncology 2011 6 117 http content 6 1 117 RADIATION ONCOLOGY RESEARCH Open Access Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas ONSM Sebastian Adeberg Thomas Welzel Stefan Rieken Jurgen Debus and Stephanie E Combs Abstract Purpose We analyzed our long-term experience with fractionated stereotactic radiotherapy FSRT in patients with meningioma of the optic nerve sheath ONSM . Patients and Methods Between January 1991 and January 2010 40 patients with ONSM were treated using FSRT. Of these 19 patients received radiotherapy as primary treatment and 21 patients were treated after surgical resection. The median target volume was ml median total dose was 54 Gy in median single fractions of 1 8 Gy. Results Local progression-free survival was 100 . Median survival after FSRT was 60 months range 4-228 months . In all patients overall toleration of FSRT was very good. Acute toxicity was mild. Prior to RT 29 patients complained about any kind of visual impairment including visual field deficits diplopia or amaurosis. Prior surgical resection was identified as a negative prognostic factor for visual outcome whereas patients with larger tumor volumes demonstrated a higher number of patients with improvement of pre-existing visual deficits. Conclusion Long-term outcome after FSRT for ONSM shows improved vision in patients not treated surgically prior to RT moreover the best improvement of visual deficits are observed in patients with larger target volumes. The absence of tumor recurrences supports that FSRT is a strong alternative to surgical resection especially in small tumors without extensive compression of normal tissue structures Keywords Meningioma visual outcome toxicity local control Introduction Treatment of primary optic nerve sheath meningiomas ONSM remains a challenge in the interdisciplinary team of surgeons .
