Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " SCLC extensive disease – treatment guidance by extent or/and biology of response. | Radiation Oncology BioMed Central Commentary SCLC extensive disease - treatment guidance by extent or and biology of response Franziska Eckert and Arndt-Christian Muller Open Access Address Department of Radiooncology Eberhard-Karls-University Tubingen Germany Email Franziska Eckert - Arndt-Christian Muller - Corresponding author Published 2 October 2008 Received I April 2008 Radiation Oncology 2008 3 33 doi 1748-717X-3-33 Accepted 2 October 2008 This article is available from http content 3 I 33 2008 Eckert and Muller licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In extensive disease of small cell lung cancer a doubling of the one-year-survival rate was reported in August 2007 by prophylactic cranial irradiation applied to patients who experienced any response to initial chemotherapy. We discuss the treatment concept of extensive disease in the face of the latest results and older studies with additional thoracic irradiation in this subgroup. A randomized trial with prophylactic cranial irradiation published in 1999 demonstrated an improvement of 5-year-overall-survival for complete responders at least at distant levels receiving additional thoracic radiochemotherapy compared to chemotherapy alone vs. . But these results were almost neglected and thoracic radiotherapy was not further investigated for good responders of extensive disease. However in the light of current advances by prophylactic cranial irradiation these findings are noteworthy on all accounts. Considering both a possible interpretation of these data could be a survival benefit of local control by simultaneous thoracic .
