Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis. | Radiation Oncology BioMed Central Research AT-101 a small molecule inhibitor of anti-apoptotic Bcl-2 family members activates the SAPK JNK pathway and enhances radiation-induced apoptosis Shuraila F Zerp1 Rianne Stoter2 Gitta Kuipers2 Dajun Yang3 Marc E Lippman4 Wim J van Blitterswijk1 Harry Bartelink1 Rogier Rooswinkel5 Vincent Lafleur2 and Marcel Verheij 1 2 Address Department of Radiation Oncology The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands 2Department of Radiation Oncology VU University Medical Center Amsterdam The Netherlands 3Ascenta Therapeutics Inc. Malvern Pennsylvania USA 4Department of Internal Medicine University of Michigan Health System Ann Arbor Michigan USA and 5Division of Immunology The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital Amsterdam The Netherlands Email Shuraila F Zerp - Rianne Stoter - Gitta Kuipers - Dajun Yang - dyang@ Marc E Lippman - lippmanm@ Wim J van Blitterswijk - Harry Bartelink - Rogier Rooswinkel - Vincent Lafleur - Marcel Verheij - Corresponding author Open Access Published 23 October 2009 Received 3 June 2009 Accepted 23 October 2009 Radiation Oncology 2009 4 47 doi 1748-717X-4-47 This article is available from http content 4 1 47 2009 Zerp et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gossypol a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and .