Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài:" The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells. | Radiation Oncology BioMed Central Research The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells James W Welsh 1 Daruka Mahadevan2 Ron Ellsworth2 Laurence Cooke3 David Bearss4 and Baldassarre Stea5 Address 1Departmentr of Radiation Oncology The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Blvd. Houston TX USA 2Department of Medicine University of Arizona Cancer Center 1515 North Campbell Avenue Tucson AZ 85724-5024 USA 3University of Arizona College of Medicine 1501 North Campbell Avenue Tucson AZ 85724-5024 USA 4SuperGen Inc 4140 Dublin Boulevard Dublin CA 94568-7757 USA and 5Department of Radiation Oncology University of Arizona Cancer Center 1515 North Campbell Avenue Tucson AZ 85724-5024 USA Email James W Welsh - jwelsh@ Daruka Mahadevan - DMahadevan@ Ron Ellsworth - rellswo@ Laurence Cooke - lcooke@ David Bearss - Baldassarre Stea - bstea@ Corresponding author Open Access Published 22 December 2009 Received 27 August 2009 Accepted 22 December 2009 Radiation Oncology 2009 4 69 doi 1748-717X-4-69 This article is available from http content 4 1 69 2009 Welsh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Purpose Glioblastoma multiforme GBM is resistant to current cytotoxic therapies in part because of enhanced DNA repair. Activation of the receptor tyrosine kinase c-Met has been shown to protect cancer cells from DNA damage. We hypothesized that inhibiting c-Met would decrease this protection and thus sensitize resistant tumor cells to the effects
