Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial Yoo-Sin Park1, Si-Woong Lim2,3, Il-Hoon Lee2,4, Tae-Jin Lee5, Jong-Sung Kim6 and Jin Soo Han7 of Biomedical Science, College of Medicine 1F, Hanyang University, Haengdang-dong 17, Seongdong-gu, Seoul, 133-791, South Korea of Physical Medicine and Rehabilitation, School of Medicine, Inje University, Gaekeum-dong 633-165, Pusanjin-gu, Pusan, 614-735, South Korea 3Chamsarang PM&R Clinic, Chonho-dong 455, Gangdong-gu, Seoul, 134-020, South Korea 4Kwangmyung PM&R Clinic, Kwangmyung-dong 340-5, Kwangmyung, Gyunggi-do, 423-016, South Korea 5Department of Pathology, School of Medicine, Chungang University, Heukseok-dong,. | Available online http content 9 1 R8 Open Access Research article Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits a randomized controlled trial Yoo-Sin Park1 Si-Woong Lim2 3 Il-Hoon Lee2 4 Tae-Jin Lee5 Jong-Sung Kim6 and Jin Soo Han7 institute of Biomedical Science College of Medicine 1 F Hanyang University Haengdang-dong 17 Seongdong-gu Seoul 133-791 South Korea 2Department of Physical Medicine and Rehabilitation School of Medicine Inje University Gaekeum-dong 633-165 Pusanjin-gu Pusan 614-735 South Korea 3Chamsarang PM R Clinic Chonho-dong 455 Gangdong-gu Seoul 134-020 South Korea 4Kwangmyung PM R Clinic Kwangmyung-dong 340-5 Kwangmyung Gyunggi-do 423-016 South Korea 5Department of Pathology School of Medicine Chungang University Heukseok-dong Dongjak-gu Seoul 155-756 South Korea laboratory Animal Research Center Samsung Biomedical Research Institute Samsung Medical Center Ilwon-dong 50 Gangnam-gu Seoul 135710 South Korea 7Department of Laboratory Animal Medicine College of Veterinary Medicine Konkuk University Hwayang-dong 1 Gwangjin-gu Seoul 143-701 South Korea Corresponding author Yoo-Sin Park hidocys@ Received 30 Jun 2006 Revisions requested 10 Aug 2006 Revisions received 15 Dec 2006 Accepted 26 Jan 2007 Published 26 Jan 2007 Arthritis Research Therapy 2007 9 R8 doi ar2114 This article is online at http content 9 1 R8 2007 Park et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Osteoarthritis OA is a degenerative disease that disrupts the collagenous matrix of articular cartilage and is difficult to .
