Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients. | Available online http content 9 1 R18 Research article Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients Martin K Andersson1 2 Pernilla Lundberg2 Acke Ohlin3 Mark J Perry4 Anita Lie2 André Stark1 and Ulf H Lerner2 department of Orthopaedic Surgery Karolinska Hospital Karolinska Institute 171 76 Stockholm Sweden department of Oral Cell Biology Umea University Umea 901 87 Sweden department of Orthopaedics Malmo University Hospital Lund University Lund 205 02 Sweden departments of Anatomy and Clinical Sciences North Bristol University of Bristol Bristol BS2 8EJ UK Corresponding author Ulf H Lerner Received 9 Mar 2006 Revisions requested 18 Apr 2006 Revisions received 21 Dec 2006 Accepted 22 Feb 2007 Published 22 Feb 2007 Arthritis Research Therapy 2007 9 R18 doi ar2127 This article is online at http content 9 1 R1 8 2007 Andersson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Aseptic loosening of a joint prosthesis is associated with remodelling of bone tissue in the vicinity of the prosthesis. In the present study we investigated the effects of synovial fluid SF from patients with a loose prosthetic component and periprosthetic osteolysis on osteoclast and osteoblast activities in vitro and made comparisons with the effects of SF from patients with osteoarthritis OA . Bone resorption was assessed by the release of calcium 45 45Ca from cultured calvariae. The mRNA expression in calvarial bones of molecules known to be involved in osteoclast and osteoblast differentiation was assessed using .
