Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bone morphogenetic proteins in destructive and remodeling arthritis. | Available online http content 9 2 207 Review Bone morphogenetic proteins in destructive and remodeling arthritis Rik JU Lories and Frank P Luyten Laboratory for Skeletal Development and Joint Disorders Division of Rheumatology Department of Musculoskeletal Sciences Katholieke Universiteit Leuven Belgium Corresponding author Frank P Luyten Published 20 March 2007 Arthritis Research Therapy 2007 9 207 doi ar2135 This article is online at http content 9 2 207 2007 BioMed Central Ltd Abstract Joint destruction and tissue responses determine the outcome of chronic arthritis. Joint inflammation and damage are often the dominant clinical presentation. However in some arthritic diseases in particular the spondyloarthritides joint remodeling is a prominent feature with new cartilage and bone formation leading to ankylosis and contributing to loss of function. A role for bone morphogenetic proteins in joint remodeling has been demonstrated in the formation of both enthesophytes and osteophytes. Data from genetic models support a role for bone morphogenetic protein signaling in cartilage homeostasis. Finally this signaling pathway is likely to play a steering role in the synovium. Introduction The classic signs and symptoms of arthritis - rubor tumor calor dolor et functio laesa - cover a vast world of dynamic systemic and local processes with complex interactions between networks at the cellular and molecular levels. Major advances in our understanding of the pathology of chronic arthritis and new imaging techniques have highlighted distinct mechanisms of disease. In the joint these include the development and persistence of an inflammatory and immune reaction the activation of tissue destructive enzymes and cells and the suppression or stimulation of molecular pathways regulating homeostasis repair and remodeling Figure 1 . Mechanisms of inflammation and auto-immunity have been studied most .
