Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies. | Available online http content 9 2 208 Review Immune mechanisms in the pathogenesis of idiopathic inflammatory myopathies Cecilia Grundtman Vivianne Malmstrom and Ingrid E Lundberg Rheumatology Unit Department of Medicine Karolinska University Hospital Solna Karolinska Institutet SE-171 76 Stockholm Sweden Corresponding author Cecilia Grundtman Published 26 March 2007 This article is online at http content 9 2 208 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 208 doi ar2139 Abstract Idiopathic inflammatory myopathies IIMs comprising polymyositis dermatomyositis and inclusion-body myositis are characterized by inflammatory cell infiltrates in skeletal muscle tissue muscle weakness and muscle fatigue. The cellular infiltrates often consist of T lymphocytes and macrophages but also in some cases B lymphocytes. Emerging data have led to improved phenotypic characterization of the inflammatory cells including their effector molecules in skeletal muscle peripheral blood and other organs that are frequently involved such as skin and lungs. In this review we summarize the latest findings concerning the role of T lymphocytes B lymphocytes dendritic cells and other antigenpresenting cells in the pathophysiology of IIMs. Introduction Idiopathic inflammatory myopathies IIMs are characterized by mononuclear inflammatory cell infiltrates in skeletal muscle tissue by muscle weakness and by muscle fatigue. They are often subclassified into three major groups on the basis of clinical and histopathological differences polymyositis dermatomyositis and inclusion-body myositis. The cellular infiltrates in muscle tissue are mainly composed of T lymphocytes and macrophages but also in some cases B lymphocytes. This observation together with frequently detected autoantibodies particularly in polymyositis and dermatomyositis suggests that the inflammatory myopathies are immune-mediated they are .
