Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Developments in the synovial biology field 2006. | Available online http content 9 2 2 Review Developments in the synovial biology field 2006 Anette Knedla Elena Neumann and Ulf Muller-Ladner Department for Internal Medicine and Rheumatology Justus-Liebig-University Giessen Kerckhoff-Clinic Bad Nauheim Benekestr. 2-8 D-61231 Bad Nauheim Germany Corresponding author Anette Knedla Published 10 April 2007 This article is online at http content 9 2 209 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 209 doi ar2140 Abstract Synovial pathophysiology is a complex and synergistic interplay of different cell populations with tissue components mediated by a variety of signaling mechanisms. All of these mechanisms drive the affected joint into inflammation and drive the subsequent destruction of cartilage and bone. Each cell type contributes significantly to the initiation and perpetuation of this deleterious concert especially in rheumatoid arthritis. Rheumatoid arthritis synovial fibroblasts and macrophages both cell types with pivotal roles in inflammation and destruction but also T cells and B cells are crucial for complex network in the inflamed synovium. An even more complex cellular crosstalk between these key players maintains a process of chronic inflammation. As outlined in the present review in the past year substantial progress has been made to elucidate further details of the rich pathophysiology of rheumatoid arthritis which may also facilitate the identification of novel targets for future therapeutic strategies. Introduction The shift from physiology to pathophysiology - driving factors In a healthy joint the synovium covers the joint cavity and regulates the transport of nutrients and other molecules between the joint cavity and the adjacent tissue. The synovium consists of few cell layers of fibroblast-like synoviocytes and macrophage-like synoviocytes 1 . Of these the fibroblast-like synoviocytes also termed .
