Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The identification and characterization of a novel protein, c19orf10, in the synovium. | Available online http content 9 2 R30 Research article The identification and characterization of a novel protein c19orf10 in the synovium Tracey Weiler1 Qiujiang Du1 Oleg Krokhin1 Werner Ens2 Ken Standing2 Hani El-Gabalawy1 3 and John A Wilkins1 3 Department of Internal Medicine and Manitoba Centre for Proteomics and Systems Biology University of Manitoba Room 799 John Buhler Research Centre 715 McDermot Avenue Winnipeg Manitoba R3E 3P4 Canada department of Physics and Astronomy University of Manitoba 510 Allen Building Winnipeg Manitoba R3T 2N2 Canada 3Section of Rheumatology Department of Internal Medicine Faculty of Medicine University of Manitoba RR1 49 Rehab Hospital 800 Sherbrook Street Winnipeg Manitoba R3A 1 M4 Canada Corresponding author John A Wilkins jwilkin@ Received 16 Jul 2006 Revisions requested 24 Jul 2006 Revisions received 14 Feb 2007 Accepted 15 Mar 2007 Published 15 Mar 2007 Arthritis Research Therapy 2007 9 R30 doi ar2145 This article is online at http content 9 2 R30 2007 Weiler et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Joint inflammation and destruction have been linked to the deregulation of the highly synthetic fibroblast-like synoviocytes FLSs and much of our current understanding of the mechanisms that underlie synovitis has been collected from studies of FLSs. During a proteomic analysis of FLS cells we identified a novel protein c19orf10 chromosome 19 open reading frame 10 that was produced in significant amounts by these cells. The present study provides a partial characterization of c19orf10 in FLSs synovial fluid and the synovium. Murine monoclonal and chicken polyclonal antibodies were .
