Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes. | Available online http content 9 2 R33 Research article Microenvironmental changes during differentiation of mesenchymal stem cells towards chondrocytes Farida Djouad1 2 Bruno Delorme3 Marielle Maurice4 Claire Bony1 2 Florence Apparailly1 2 Pascale Louis-Plence1 2 Franpois Canovas5 Pierre Charbord3 Danièle Noel1 2 and Christian Jorgensen1 2 5 Open Access 1Inserm U 844 80 avenue Augustin Fliche Montpellier F-34091 France 2Université Montpellier 1 2 rue Ecole de Médecine Montpellier F-34000 France 3Inserm ESPRI EA3855 10 bld Tonnellé Tours F-37032 France 4Genopoietic 1390 rue Centrale Beynost-Miribel F-01708 France 5CHU Montpellier Hôpital Lapeyronie avenue du Doyen Gaston Giraud Montpellier F-34295 France Contributed equally Corresponding author Danièle Noel noel@ Received 14 Dec 2006 Revisions requested 24 Jan 2007 Revisions received 20 Feb 2007 Accepted 29 Mar 2007 Published 29 Mar 2007 Arthritis Research Therapy 2007 9 R33 doi ar2153 This article is online at http content 9 2 R33 2007 Djouad et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Chondrogenesis is a process involving stem-cell differentiation through the coordinated effects of growth differentiation factors and extracellular matrix ECM components. Recently mesenchymal stem cells MSCs were found within the cartilage which constitutes a specific niche composed of ECM proteins with unique features. Therefore we hypothesized that the induction of MSC differentiation towards chondrocytes might be induced and or influenced by molecules from the microenvironment. Using microarray analysis we previously identified genes that are regulated during MSC differentiation towards chondrocytes. .
