Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis. | Available online http content 9 2 R39 Research article Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis Lisa Carroll1 Ian H Frazer1 Malcolm Turner1 Thomas H Marwick2 and Ranjeny Thomas1 1Diamantina Institute for Cancer Immunology and Metabolic Medicine University of Queensland Princess Alexandra Hospital Ipswich Road Brisbane Queensland 4102 Australia department of Medicine University of Queensland Princess Alexandra Hospital Ipswich Road Brisbane Queensland 4102 Australia Corresponding author Ranjeny Thomas Received 18 Oct 2006 Revisions requested 23 Nov 2006 Revisions received 20 Mar 2007 Accepted 11 Apr 2007 Published 11 Apr 2007 Arthritis Research Therapy 2007 9 R39 doi ar2175 This article is online at http content 9 2 R39 2007 Carroll et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Patients with rheumatoid arthritis RA are at risk of excess mortality predominantly owing to cardiovascular CV events. The receptor for advanced glycation end products RAGE has been implicated in the perpetuation of the chronic inflammatory response in vascular disease. A Gly82 Ser polymorphism in the RAGE gene which is associated with enhanced RAGE signaling is present more frequently in patients with RA than the general population. To investigate whether RAGE Gly82 Ser polymorphism is associated with CV events in RA we examined CV events CV risk factors features of RA and RAGE Gly82 Ser polymorphism in 232 patients with RA attending a tertiary referral hospital. CV events the duration and severity of RA and risk factors for CV disease were determined using
