Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Current status of lupus genetics. | Available online http content 9 3 210 Review Current status of lupus genetics Andrea L Sestak1 Swapan K Nath2 Amr H Sawalha1 3 4 and John B Harley1 3 4 10klahoma Medical Research Foundation Arthritis and Immunology Research Program 825 NE 13th St Oklahoma City Oklahoma 73104 USA 2Oklahoma Medical Research Foundation Genetic Epidemiology Unit Arthritis and Immunology Research Program 825 NE 13th St Oklahoma City Oklahoma 73104 USA 3US Department of Veterans Affairs Medical Center Department of Medicine University of Oklahoma Health Sciences Center 921 NE 13th St Oklahoma City Oklahoma 73104 USA 4Department of Internal Medicine University of Oklahoma Health Sciences Center 1100 N Lindsay Oklahoma City Oklahoma 73104 USA Corresponding author Andrea L Sestak andrea-sestak@ Published 14 May 2007 This article is online at http content 9 3 210 2007 BioMed Central Ltd. Arthritis Research Therapy 2007 9 210 doi ar2176 Abstract Over the past 40 years more than 100 genetic risk factors have been defined in systemic lupus erythematosus through a combination of case studies linkage analyses of multiplex families and case-control analyses of single genes. Multiple investigators have examined patient cohorts gathered from around the world and although we doubt that all of the reported associations will be replicated we have probably already discovered many of the genes that are important in lupus pathogenesis including those encoding human leukocyte antigen-DR Fcy receptor 3A protein tyrosine phosphatase nonreceptor 22 cytotoxic T lymphocyte associated antigen 4 and mannose-binding lectin. In this review we will present what is known what is disputed and what remains to be discovered in the world of lupus genetics. Introduction Systemic lupus erythematosus SLE has long been appreciated to arise from both genetic and environmental factors. Although environmental factors such as the Epstein-Barr virus are clearly .
