Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Major biological obstacles for persistent cell-based regeneration of articular cartilage. | Available online http content 9 3 213 Review Major biological obstacles for persistent cell-based regeneration of articular cartilage Andre F Steinert1 Steven C Ghivizzani2 Axel Rethwilm3 Rocky S Tuan4 Christopher H Evans5 and Ulrich Noth1 Orthopaedic Center for Musculoskeletal Research Konig-Ludwig-Haus Julius-Maximilians-University Wurzburg Germany 2Department of Orthopaedics and Rehabilitation University of Florida Gainesville FL USA 3Institut fur Virologie und Immunbiologie Julius-Maximilians-University Wurzburg Germany 4Cartilage Biology and Orthopaedics Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Department of Health and Human Services Bethesda MD USA 5Center for Molecular Orthopaedics Harvard Medical School Boston MA USA Corresponding author Andre F Steinert Published 5 June 2007 This article is online at http content 9 3 213 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 213 doi ar2195 Abstract Hyaline articular cartilage the load-bearing tissue of the joint has very limited repair and regeneration capacities. The lack of efficient treatment modalities for large chondral defects has motivated attempts to engineer cartilage constructs in vitro by combining cells scaffold materials and environmental factors including growth factors signaling molecules and physical influences. Despite promising experimental approaches however none of the current cartilage repair strategies has generated long lasting hyaline cartilage replacement tissue that meets the functional demands placed upon this tissue in vivo. The reasons for this are diverse and can ultimately result in matrix degradation differentiation or integration insufficiencies or loss of the transplanted cells and tissues. This article aims to systematically review the different causes that lead to these impairments including the lack of .
