Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice. | Available online http content 9 3 R50 Research article Inhibition of indoleamine 2 3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice Sándor Szántó1 2 Tamás Koreny1 Katalin Mikecz1 Tibor T Glant1 Zoltán Szekanecz2 and John Varga3 Section of Molecular Medicine Department of Orthopedic Surgery Rush University Medical Center Cohn Research Building Room 708 1 735 W. Harrison Chicago IL 60612 USA institute of Medicine Division of Rheumatology University of Debrecen Medical and Health Science Center 22 Móricz Street Debrecen H-4012 Hungary 3Division of Rheumatology Northwestern University Medical School 303 East Chicago Ave. Chicago IL 60611 USA Corresponding author Sándor Szántó szanto@ Received 13 Dec 2006 Revisions requested 17 Jan 2007 Revisions received 24 Apr 2007 Accepted 18 May 2007 Published 18 May 2007 Arthritis Research Therapy 2007 9 R50 doi ar2205 This article is online at http content 9 3 R50 2007 Szántó et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Indoleamine 2 3-dioxygenase IDO is one of the initial and ratelimiting enzymes involved in the catabolism of the essential amino acid tryptophan. In cultured cells the induction of IDO leads to depletion of tryptophan and tryptophan starvation. Recent studies suggest that modulation of tryptophan concentration via IDO plays a fundamental role in innate immune responses. Induction of IDO by interferon-Y in macrophages and dendritic cells results in tryptophan depletion and suppresses the immune-mediated activation of fibroblasts and T B and natural killer cells. To assess the role of IDO in collagen-induced arthritis CIA a model of .