Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden. | Available online http content 9 3 R56 Research article The PTPN22 1858C T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden Heidi Kokkonen1 Martin Johansson1 Lena Innala1 Erik Jidell2 and Solbritt Rantapaa-Dahlqvist1 Department of Rheumatology University Hospital SE-901 85 Umea Sweden 2Department of Transfusion Medicine University Hospital SE-901 85 Umea Sweden Corresponding author Solbritt Rantapăă-Dahlqvist Received 30 Jan 2007 Revisions requested 19 Mar 2007 Revisions received 10 May 2007 Accepted 6 Jun 2007 Published 6 Jun 2007 Arthritis Research Therapy 2007 9 R56 doi ar2214 This article is online at http content 9 3 R56 2007 Kokkonen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The PTPN22 1858C T polymorphism has been associated with several autoimmune diseases including rheumatoid arthritis RA . We have shown that carriage of the T variant CT or TT of PTPN22 in combination with anti-cyclic citrullinated peptide anti-CCP antibodies highly increases the odds ratio for developing RA. In the present study we analysed the association between the PTPN22 1858C T polymorphism and early RA in patients from northern Sweden related the polymorphism to autoantibodies and the HLA-DR shared epitope and analysed their association with markers for disease activity and progression. The inception cohort includes individuals who also donated samples before disease onset. A case-control study was performed in patients n 505 342 females and 163 males with early RA mean duration of symptoms months and in population-based matched .
