Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus. | Available online http content 9 4 R84 Research article Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus Jan Renier AJ Moonen1 Karina de Leeuw2 Xavier J Gallego Y van Seijen1 Cees GM Kallenberg2 Marja JA van Luyn1 Marc Bijl2 and Martin C Harmsen1 department of Pathology and Laboratory Medicine University Medical Center Groningen University of Groningen The Netherlands department of Clinical Immunology University Medical Center Groningen University of Groningen The Netherlands Corresponding author Jan Renier AJ Moonen Received 16 May 2007 Revisions requested 3 Jul 2007 Revisions received 27 Jul 2007 Accepted 31 Aug 2007 Published 31 Aug 2007 Arthritis Research Therapy 2007 9 R84 doi ar2283 This article is online at http content 9 4 R84 2007 Moonen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Systemic lupus erythematosus SLE is associated with premature and accelerated atherosclerosis. Circulating progenitor cells CPCs are circulating bone-marrow derived cells that play an important role in the repair of vascular damage that underlies the development of atherosclerosis. The objective of this study was to determine the number and functionality of CPCs in patients with SLE. The study included 44 female SLE patients in an inactive stage of disease and 35 age-matched female controls. CPC numbers in the circulation were determined by FACS with monoclonals against CD14 CD34 and CD133. Peripheral blood-derived mononuclear cell PBMNC fractions were cultured in angiogenic medium. The endothelial-like phenotype was confirmed and the colony forming unit CFU .
