Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: ITGAV polymorphism and disease susceptibility in a Japanese rheumatoid arthritis population. | Available online http content 9 5 405 Letter ITGAV polymorphism and disease susceptibility in a Japanese rheumatoid arthritis population Noriko likuni Shu Kobayashi Katsunori Ikari Taisuke Tomatsu Masako Hara Hisashi Yamanaka Naoyuki Kamatani and Shigeki Momohara Institute of Rheumatology Tokyo Women s Medical University 10-22 Kawada Tokyo 162-0054 Japan Corresponding author Katsunori Ikari kikari@ Published 31 October 2007 Arthritis Research Therapy 2007 9 405 doi ar2303 This article is online at http content 9 5 405 2007 BioMed Central Ltd See related research article by Jacq et al. http content 9 4 R63 and related editorial by Ahnert and Kirsten http content 9 5 108 A research article by Jacq and colleagues 1 recently published in this journal reported an association between rheumatoid arthritis RA and the rs3738919-C allele in the ITGAV gene which encodes the av subunit of the integrin avP3 in a European Caucasian population. One feature of the pathophysiology of RA is the hyperangiogenesis observed in the synovial tissue and along with excess macrophages and T lymphocytes avP3 ligands are also abundant in synovial fluid 2 . As a key player in angiogenesis 3 it has been suggested that ITGAV may be a RA susceptibility gene. The linkage study also supports this view because the 2q31 region containing ITGAV exhibited linkage in a dense genome scan 4 . Although the European association study by Jacq and colleagues 1 indicated ITGAV to be a new minor RA susceptibility gene a replication study conducted in a population of different ethnicity is helpful in exploring whether the association is caused by a common variance through various ethnic groups. We therefore undertook a large population-based study to investigate the association between ITGAV and RA in a Japanese population. DNA samples were obtained from 1 504 Japanese RA patients and 449 population
