Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " The role of PDGF in radiation oncology. | Radiation Oncology BioMed Central Review The role of PDGF in radiation oncology Minglun Li Verena Jendrossek and Claus Belka Open Access Address Department of Radiation Oncology University Hospital Tuebingen Germany Email Minglun Li - Verena Jendrossek - Claus Belka - Corresponding author Published II January 2007 Received 15 November 2006 Radiation Oncology 2007 2 5 doi 1748-717X-2-5 Accepted 1 1 January 2007 This article is available from http content 2 I 5 2007 Li et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Platelet-derived growth factor PDGF was originally identified as a constituent of blood serum and subsequently purified from human platelets. PDGF ligand is a dimeric molecule consisting of two disulfide-bonded chains from A- B- C- and D-polypeptide chains which combine to homo- and heterodimers. The PDGF isoforms exert their cellular effects by binding to and activating two structurally related protein tyrosine kinase receptors. PDGF is a potent mitogen and chemoattractant for mesenchymal cells and also a chemoattractant for neutrophils and monocytes. In radiation oncology PDGF are important for several pathologic processes including oncogenesis angiogenesis and fibrogenesis. Autocrine activation of PDGF was observed and interpreted as an important mechanism involved in brain and other tumors. PDGF has been shown to be fundamental for the stability of normal blood vessel formation and may be essential for the angiogenesis in tumor tissue. PDGF also plays an important role in the proliferative disease
