Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Src kinase inhibition promotes the chondrocyte phenotype. | Available online http content 9 5 R105 Research article Src kinase inhibition promotes the chondrocyte phenotype Laura Bursell1 Anita Woods1 Claudine G James1 Daphne Pala1 Andrew Leask1 2 and Frank Beier1 2 Department of Physiology and Pharmacology Canadian Institutes of Health Research Group in Skeletal Development and Remodeling Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada N6A 5C1 department of Oral Biology Canadian Institutes of Health Research Group in Skeletal Development and Remodeling Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada N6A 5C1 Corresponding author Frank Beier fbeier@ Revisions requested 29 Jun 2007 Revisions received 16 Aug 2007 Accepted 10 Oct 2007 Published 10 Oct 2007 Arthritis Research Therapy 2007 9 R105 doi ar2308 This article is online at http content 9 5 R105 2007 Bursell et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Regulated differentiation of chondrocytes is essential for both normal skeletal development and maintenance of articular cartilage. The intracellular pathways that control these events are incompletely understood and our ability to modulate the chondrocyte phenotype in vivo or in vitro is therefore limited. Here we examine the role played by one prominent group of intracellular signalling proteins the Src family kinases in regulating the chondrocyte phenotype. We show that the Src family kinase Lyn exhibits a dynamic expression pattern in the chondrogenic cell line ATDC5 and in a mixed population of embryonic mouse chondrocytes in high-density monolayer culture. Inhibition of Src kinase activity using .
