Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. | Available online http content 9 5 R110 Research article Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia Gilberto Vargas-Alarcón1 José-Manuel Fragoso1 David Cruz-Robles1 Angelica Vargas1 Alfonso Vargas1 José-Ignacio Lao-Villadóniga2 Ferran Garcia-Fructuoso3 Manuel Ramos-Kuri4 Fernando Hernandez4 Rashidi Springall1 Rafael Bojalil1 Maite Vallejo1 and Manuel Martinez-Lavin1 1National Institute of Cardiology Juan Badiano 1 Mexico City 1 4080 Mexico 2Dr. Echevarne Laboratory Provenza 312 Barcelona E08037 Spain 3CIMA Clinic Manuel Girona 33 Barcelona E08034 Spain 4Panamerican University Donatelo 59 Mexico City 03920 Mexico Corresponding author Manuel Martinez-Lavin mmlavin@ Received 19 Apr 2007 Revisions requested 25 May 2007 Revisions received 20 Jun 2007 Accepted 26 Oct 2007 Published 26 Oct 2007 Arthritis Research Therapy 2007 9 R110 doi ar2316 This article is online at http content 9 5 R110 2007 Vargas-Alarcón et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Autonomic dysfunction is frequent in patients with fibromyalgia FM . Heart rate variability analyses have demonstrated signs of ongoing sympathetic hyperactivity. Catecholamines are sympathetic neurotransmitters. Catechol-O-methyltransferase COMT an enzyme is the major catecholamine-clearing pathway. There are several single-nucleotide polymorphisms SNPs in the COMT gene associated with the different catecholamine-clearing abilities of the COMT enzyme. These SNPs are in linkage disequilibrium and segregate as haplotypes . Healthy females with a particular COMT gene haplotype ACCG producing a defective enzyme are more sensitive to .
