Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Toll-like receptors and innate immune responses in systemic lupus . | Available online http content 9 6 222 Review Toll-like receptors and innate immune responses in systemic lupus erythematosus Robert Lafyatis1 and Ann Marshak-Rothstein2 1 Boston University School of Medicine Department of Medicine Rheumatology Section 715 Albany Street Boston Massachusetts 02118 USA 2Boston University School of Medicine Department of Microbiology 715 Albany Street Boston Massachusetts 02118 USA Correspondence Robert Lafyatis lafyatis@ Published 29 November 2007 This article is online at http content 9 6 222 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 222 doi ar2321 Abstract A series of discoveries over the past several years has provided a new paradigm for understanding autoimmunity in systemic lupus erythematosus. The discoveries of pattern recognition receptors and of how these receptors can be recruited into autoimmune responses underpin this paradigm. The implications of these observations continue to unfold with ongoing investigation into the range and specificity of pattern recognition receptors into how immune complexes containing nucleic acids trigger these receptors into how endogenous macromolecular danger signals stimulate innate immune responses and into the effect of pattern recognition receptor activation on various cell types in initiating and perpetuating autoimmunity. The development of clinical trials using therapeutic agents that target components of the innate immune system suggests that these advances may soon culminate in new medications for treating patients with systemic lupus erythematosus. Introduction Pattern recognition receptors are the key to innate immune system recognition of microbes. The strength of these receptors in terms of their ability to respond to molecular motifs common to pathogens may also prove to be the weakness that results in autoimmunity because they are potentially less discrete than the cognate immune system in distinguishing
