Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Increased lymphangiogenesis in joints of mice with inflammatory arthritis. | Available online http content 9 6 R118 Research article Increased lymphangiogenesis in joints of mice with inflammatory arthritis Qian Zhang1 Yan Lu1 Steven T Proulx2 Ruolin Guo1 Zhenqiang Yao1 Edward M Schwarz2 Brendan F Boyce1 2 and Lianping Xing1 2 Department of Pathology and Laboratory Medicine. University of Rochester Medical Center 601 Elmwood Avenue Rochester NY 14642 USA 2Center for Musculoskeletal Research University of Rochester Medical Center 601 Elmwood Avenue Rochester NY 14642 USA Corresponding author Lianping Xing Lianping_Xing@ Received 7 Aug 2007 Revisions requested 20 Sep 2007 Revisions received 1 Oct 2007 Accepted 12 Nov 2007 Published 1 2 Nov 2007 Arthritis Research Therapy 2007 9 R118 doi ar2326 This article is online at http content 9 6 R118 2007 Zhang et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Angiogenesis is involved in the pathogenesis of inflammatory arthritis but little is known about the role of lymphangiogenesis in this setting. Here we examined whether tumor necrosis factor TNF stimulates osteoclast precursors OCPs to produce the lymphatic growth factor vascular endothelial growth factor-C VEGF-C and induce lymphangiogenesis. We used TNF-transgenic Tg mice and mice with serum-induced arthritis. OCPs were purified by fluorescence-activated cell sorting of CD11b Gr-1 lo blood or bone marrow cells and subjected to microarray analysis or were generated from spleen or joint cells and treated with TNF. Expression of VEGFs was analyzed and examined by real-time reverse transcription-polymerase chain reaction and Western blotting. Immunostaining and magnetic resonance imaging were used to quantify .
