Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gait analysis in a murine model of collagen-induced arthritis. | Available online http content 9 6 R1 23 Research article Gait analysis in a murine model of collagen-induced arthritis Jon Vincelette1 Yifan Xu1 Le-Ning Zhang1 Caralee J Schaefer1 Ronald Vergona1 Mark E Sullivan1 Thomas G Hampton2 and Yi-Xin Jim Wang1 1Bayer Healthcare Pharmaceuticals 800 Dwight Way Berkeley CA 94701 USA 2Mouse Specifics Inc. 28 State St. Suite 1112 Boston MA 02109 USA Corresponding author Le-Ning Zhang zhanglening@ Received 12 Sep 2007 Revisions requested 8 Oct 2007 Revisions received 4 Nov 2007 Accepted 24 Nov 2007 Published 24 Nov 2007 Arthritis Research Therapy 2007 9 R123 doi ar2331 This article is online at http content 9 6 R123 2007 Vincelette et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Murine collagen-induced arthritis CIA has become a valuable animal model for elucidating pathogenic mechanisms and evaluating therapeutic effects for rheumatoid arthritis. Recent advances in digital imaging and computer technology have enabled gait analysis to develop into a powerful tool for objectively detecting functional deficits in human and animal models. The present study explored the use of non-invasive video-capture gait analysis in the evaluation of a murine CIA model. CIA was induced in 45 female DBA 1LacJ mice 8 to 10 weeks old by immunization with lyophilized bovine articular type II collagen. Gait parameters were determined by ventral plane videography and were correlated to traditional arthritis clinical scores. Our results showed that increases in clinical scores that measure the severity of CIA corresponded to changes in multiple gait parameters that reflect both morphologic increases in paw area and .
