Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males. | Available online http content 10 1 R2 Research article Circulating RANKL is inversely related to RANKL mRNA levels in bone in osteoarthritic males David Findlay1 2 Mellick Chehade1 2 Helen Tsangari3 Susan Neale1 2 Shelley Hay1 2 Blair Hopwood3 Susan Pannach1 2 Peter O Loughlin4 and Nicola Fazzalari2 3 5 Discipline of Orthopaedics and Trauma University of Adelaide North Terrace Adelaide 5000 Australia 2Hanson Institute Frome Road Adelaide 5000 Australia division of Tissue Pathology Institute of Medical and Veterinary Science Frome Road Adelaide 5000 Australia 4Division of Clinical Biochemistry Institute of Medical and Veterinary Science Frome Road Adelaide 5000 Australia discipline of Pathology University of Adelaide North Terrace Adelaide 5000 Australia Corresponding author David Findlay Received 16 Aug 2007 Revisions requested 10 Oct 2007 Revisions received 6 Nov 2007 Accepted 8 Jan 2008 Published 8 Jan 2008 Arthritis Research Therapy 2008 10 R2 doi 1 ar2348 This article is online at http content 10 1 R2 2008 Findlay et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The relationship of circulating levels of receptor activator of nuclear factor-KB ligand RANKL and osteoprotegerin OPG with the expression of these molecules in bone has not been established. The objective of this study was to measure in humans the serum levels of RANKL and OPG and the corresponding levels in bone of mRNA encoding these proteins. Methods Fasting blood samples were obtained on the day of surgery from patients presenting for hip replacement surgery for primary osteoarthritis OA . Intraoperatively samples of intertrochanteric .
