Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitro study. | Available online http content 10 1 R9 Research article Key regulatory molecules of cartilage destruction in rheumatoid arthritis an in vitro study Kristin Andreas1 Carsten Lubke2 Thomas Haupl2 Tilo Dehne2 Lars Morawietz3 Jochen Ringe1 Christian Kaps4 and Michael Sittinger2 Open Access Tissue Engineering Laboratory and Berlin - Brandenburg Center for Regenerative Therapies Department of Rheumatology Charité -Universitatsmedizin Berlin Tucholskystrasse 2 10117 Berlin Germany 2Tissue Engineering Laboratory Department of Rheumatology Charité - Universitatsmedizin Berlin Tucholskystrasse 2 10117 Berlin Germany institute for Pathology Charité - Universitatsmedizin Berlin Charitéplatz 1 10117 Berlin Germany 4TransTissueTechnologies GmbH Tucholskystrasse 2 10117 Berlin Germany Corresponding author Kristin Andreas Received 13 Jul 2007 Revisions requested 21 Aug 2007 Revisions received 28 Dec 2007 Accepted 18 Jan 2008 Published 18 Jan 2008 Arthritis Research Therapy 2008 10 R9 doi 1 ar2358 This article is online at http content 10 1 R9 2008 Andreas et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons. Attribution License http licenses by 20 which permits unrestricted. use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Rheumatoid arthritis RA is a chronic inflammatory and systemic autoimmune disease that leads to progressive cartilage destruction. Advances in the treatment of RA-related destruction of cartilage require profound insights into the molecular mechanisms involved in cartilage degradation. Until now comprehensive data about the molecular RA-related dysfunction of chondrocytes have been limited. Hence the objective of this study was to establish a standardized in vitro model to profile the key regulatory molecules of RA-related destruction .
